DNA based multi-copper ions assembly using combined pyrazole and salen ligandosides

Chem. Sci., 2015, 6, 632-638 published on 11.08.2014
Chem. Sci.
The DNA structure is an ideal building block for the construction of functional nano-objects. In this direction, metal coordinating base pairs (ligandosides) are an appealing tool for the future specific functionalization of such nano-objects. We present here a study, in which we combine the metal ion coordinating pyrazole ligandoside with the interstrand crosslinking salen ligandoside system. We show that both ligandosides, when combined, are able to create stable multi-copper ion complexing DNA double helix structures in a cooperative fashion.
TU München