A Programmable DNA-Based Molecular Valve for Colloidal Mesoporous Silica

Angewandte Chemie International Edition, 2010, 49, 4734-4737 published on 28.06.2010
Angewandte Chemie International Edition
Letting off steam: A temperature-controlled valve system permits the targeted release of guest fluorescein molecules from the pores of colloidal mesoporous silica particles. The pore-opening temperature is dependent on the length of double-stranded DNA linkers. Avidin proteins that are joined to the DNA by a biotin modification act as the molecular valve at the exits to the pores.
TU München