beta-Lactones Decrease the Intracellular Virulence of Listeria monocytogenes in Macrophages

ChemMedChem, 2009, 4, 1260-1263 published on 26.05.2009

A chemical knockout of the virulence regulator ClpP by β-lactones in Listeria monocytogenes resulted in a reduced production of the major virulence factor listeriolysin O as well as of PI-phospholipase C. This led to a significant decrease in intracellular replication of the pathogen in mouse macrophage cells.

TU München