Crystal Structure of a Cisplatin–(1,3-GTG) Cross-Link within DNA Polymerase η
Angewandte Chemie, 2010, 49, 3077-3080 published on 12.04.2010
Flipped out: The cisplatin–(1,3-GTG) adduct, a strongly cytotoxic DNA lesion generated by the action of cisplatin therapeutics, is partially bypassed by Y-family DNA polymerase η. Crystal structure data on this DNA–protein complex explain the partial-bypass process. The central dT unit of the lesion is turned out and blocks the movement of the enzyme along the DNA duplex.