Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain

European Journal of Organic Chemistry, 2010, 49, 5375-5377 published on 19.07.2010
European Journal Of Organic Chemistry
The natural products PreQ1, PreQ0, and archaeosine are deazaguanosine-derived natural products of immense biological importance. All three are critical components of tRNAs and, as such, are involved in decoding genetic information. We were able to consolidate and shorten the syntheses of all three compounds by using a novel Turbo-Grignard-based approach. The reported iodine/magnesium exchange followed by a Grignard reaction with the deazaguanosine skeleton showed a high tolerance towards important functional groups such as esters and amides.
TU München