Efficient mono- and bis-functionalization of 3,6-dichloropyridazine using (tmp)_2 Zn 2MgCl2 2LiCl
Chem. Commun., 2008, 6387-6389 published on 04.11.2008
3,6-Dichloropyridazine undergoes a smooth metallation using (tmp)_2 Zn 2MgCl_2 2LiCl. The resulting bis-organozinc species react with various electrophiles; subsequent functionalization via a second metallation proceeds readily; further reactions with hydrazine lead to highly substituted pyrazolo[3,4-c]pyridazines derivatives.