Trifunctionalization of the Purine Scaffold Using Mg and Zn Organometallic Intermediates

Organic Letters, 2011, 13, 792-795 published on 19.01.2011
Org. Lett.
Starting from an appropriate 6-chloro-2-TMS-purine derivative, a regioselective functionalization of the purine scaffold was achieved successively at positions 8, 6, and 2 via zinc and magnesium intermediates which were generated either by a direct zincation with TMPZnCl 3 LiCl or by an I/Mg exchange with iPrMgCl.
TU München