SFB749 - Research Area B

Research Area B

Excited-state dynamics of a molecular dyad with two orthogonally-oriented fluorophores

Visible-Light-Driven “On”/“Off” Photochromism of a Polyoxometalate Diarylethene Coordination Complex

Kinetics and Mechanism of Oxirane Formation by Darzens Condensation of Ketones: Quantification of the Electrophilicities of Ketones

Quantification of the Michael-Acceptor Reactivity of α,β-Unsaturated Acyl Azolium Ions

Complete Mechanism of Hemithioindigo Motor Rotation

Which Factors Control the Nucleophilic Reactivities of Enamines?

2017

Transferring the entatic-state principle to copper photochemistry

Stereospecific Allylic Functionalization: The Reactions of Allylboronate Complexes with Electrophiles

Quantification and Theoretical Analysis of the Electrophilicities of Michael Acceptors

Biomimetic Synthesis of Complex Flavonoids Isolated from Daemonorops “Dragon's Blood”

Philicity, fugality, and equilibrium constants: when do rate-equilibrium relationships break down?

Ultrafast photochemistry with two product channels: Wavepacket motion through two distinct conical intersections

Nucleophilic Reactivities of Bis-Acceptor-Substituted Benzyl Anions

Nucleophilicity Parameters of Arylsulfonyl-Substituted Halomethyl Anions

Why Are Vinyl Cations Sluggish Electrophiles?

2016

The Nucleophilicity of Persistent α-Monofluoromethide Anions

Ambident Reactivity of Acetyl- and Formyl-Stabilized Phosphonium Ylides

Lewis Acidities of Indol-3-ylmethylium Ions and Intrinsic Barriers of Their Reactions with Phosphines and Pyridines

Influence of the N-Substituents on the Nucleophilicity and Lewis Basicity of N-Heterocyclic Carbenes

Nucleophilicity Parameters of Stabilized Iodonium Ylides for Characterizing Their Synthetic Potential

Nucleophilicity of Alkyl Zirconocene and Titanocene Precatalysts, and Kinetics of Activation by Carbenium Ions and by B(C₆F₅)₃

Quantification of the nucleophilic reactivity of nicotine

Ethenesulfonyl Fluoride: The Most Perfect Michael Acceptor Ever Found?

Philicities, Fugalities, and Equilibrium Constants

Dendronized Mesoporous Silica Nanoparticles Provide an Internal Endosomal Escape Mechanism for Successful Cytosolic Drug Release

Nucleophilic Reactivities of 2-Substituted Malonates

Genetically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release

2015

Quantification of the Nucleophilic Reactivities of Cyclic β-Keto Ester Anions

Bis(pyrazolyl)methane Copper Complexes as Robust and Efficient Catalysts for Sonogashira Couplings

Efficient Biomimetic Hydroxylation Catalysis with a Bis(pyrazolyl)imidazolylmethane Copper Peroxide Complex

Sequential Oxidative α‑Cyanation/Anti-Markovnikov
Hydroalkoxylation of Allylamines

Hole-transfer induced energy transfer in perylene diimide dyads with a donor–spacer–acceptor motif

Structure and Reactivity of Indolylmethylium Ions: Scope and Limitations in Synthetic Applications

Kinetic and Theoretical Studies of Beta-Lactone Reactivity—A Quantitative Scale for Biological Application

Reactivity scales for quantifying polar organic reactivity: the benzhydrylium methodology

Structure and Reactivity of Boron-Ate Complexes Derived from Primary and Secondary Boronic Esters

From Carbanions to Organometallic Compounds: Quantification of Metal Ion Effects on Nucleophilic Reactivities

Biomimetic Total Synthesis of Santalin Y

Benzhydrylium and tritylium ions: complementary probes for examining ambident nucleophiles

Calculated Nuclear Magnetic Resonance Spectra of Polytwistane and Related Hydrocarbon Nanorods

Early Events of DNA Photodamage

Fine-Tuning of the Nucleophilic Reactivities of Boron-Ate Complexes Derived From Aryl and Heteroaryl Boronic Esters

Photocontrolled chignolin-derived β-hairpin peptidomimetics

Stereoselective Synthesis and Reactions of Secondary Alkyllithium Reagents Functionalized at the 3-Position

Scales of Lewis Basicities toward C‑Centered Lewis Acids (Carbocations)

A magnetic stirring setup for applications in ultrafast spectroscopy of photo-sensitive solutions

2014

Photochemical formation of intricarene

Quantification of Ion-Pairing Effects on the Nucleophilic Reactivities of Benzoyl- and Phenyl-Substituted Carbanions in Dimethylsulfoxide

Insights into Nanoscale Electrophoresis of Single Dye Molecules in Highly Oriented Mesoporous Silica Channels

Structures and Reactivities of 2-Trityl- and 2-(Triphenylsilyl)pyrrolidine-Derived Enamines: Evidence for Negative Hyperconjugation with the Trityl Group

Mechanisms of Hydride Abstractions by Quinones

A broad and tunable 250- to 430-nm source for microscopy and lifetime measurements by frequency doubling of a 78-MHz-picosecond white-light laser

Total Synthesis of the Proposed Structure of Trichodermatide A

Di- and Triarylmethylium Ions as Probes for the Ambident Reactivities of Carbanions Derived from 5-Benzylated Meldrum’s Acid

Quantification of the Ambident Electrophilicities of Halogen-Substituted Quinones

New In Situ Trapping Metalations of Functionalized Arenes and Heteroarenes with TMPLi in the Presence of ZnCl2 and Other Metal Salts

Temporal and spectral correlations in bulk continua and improved use in transient spectroscopy

Hydrocarbierung von C ≡ C-Bindungen: Quantifizierung der nucleophilen Reaktivität von Inamiden

Structures and Reactivities of Iminium Ions Derived from Substituted Cinnamaldehydes and Various Chiral Imidazolidin-4-ones

Electrophilicities of 1,2-Disubstituted Ethylenes

Multifunctional Mesoporous Silica Nanoparticles as a Universal Platform for Drug Delivery

2013

A novel setup for femtosecond pump-repump-probe IR spectroscopy with few cycle CEP stable pulses

Photogeneration and reactions of benzhydryl cations and radicals: A complex sequence of mechanisms from femtoseconds to microseconds

Pulse Compression of Ultrashort UV Pulses by Self-Phase Modulation in Bulk Material

Electronic transient spectroscopy from the deep UV to the NIR: unambiguous disentanglement of complex processes

Two-dimensional Fourier transform spectroscopy in the ultraviolet with sub-20 fs pump pulses and 250–720 nm supercontinuum probe

Electrophilic Alkylations of Vinylsilanes: A Comparison of α- and β-Silyl Effects

Hiking on the potential energy surface of a functional tyrosinase model – implications of singlet, broken-symmetry and triplet description

One-Pot Two-Step Synthesis of 1-(Ethoxycarbonyl)indolizines via Pyridinium Ylides

Manifestation of Polar Reaction Pathways of 2,3-Dichloro-5,6-dicyano-ρ-benzoquinone

Structures and Ambident Reactivities of Azolium Enolates

Nucleophilicity Parameters of Pyridinium Ylides and Their Use in Mechanistic Analyses

Ion-Pairing of Phosphonium Salts in Solution: C–H⋅⋅⋅Halogen and C–H⋅⋅⋅π Hydrogen Bonds

Noncovalent Interactions in Organocatalysis: Modulating Conformational Diversity and Reactivity in the MacMillan Catalyst

Ambident Reactivities of Formaldehyde N,N-Dialkylhydrazones

Photogeneration of carbocations: applications in physical organic chemistry and the design of suitable precursors

Electrophilic Aromatic Substitutions of Aryltrifluoroborates with Retention of the BF3– Group: Quantification of the Activating and Directing Effects of the Trifluoroborate Group

Comparison of the Electrophilic Reactivities of N-Acylpyridinium Ions and Other Acylating Agents

A Comprehensive Microscopic Picture of the Benzhydryl Radical and Cation Photogeneration and Interconversion through Electron Transfer

Nucleophilic Reactivities and Lewis Basicities of 2-Imidazolines and Related N-Heterocyclic Compounds

Solvent nucleophilicities of hexafluoroisopropanol/water mixtures

Electrophilicities of Benzaldehyde-Derived Iminium Ions: Quantification of the Electrophilic Activation of Aldehydes by Iminium Formation

Towards a Comprehensive Hydride Donor Ability Scale

Regioselective Metalations of Pyrimidines and Pyrazines by Using Frustrated Lewis Pairs of BF3⋅OEt2 and Hindered Magnesium– and Zinc–Amide Bases

2012

A quantitative approach to nucleophilic organocatalysis

The Influence of Perfluorinated Substituents on the Nucleophilic Reactivities of Silyl Enol Ethers

Photogeneration of Benzhydryl Cations by Near-UV Laser Flash Photolysis of Pyridinium Salts

Struktur und Reaktivität O-methylierter Breslow-Intermediate

Nucleophilic Reactivities of Hydrazines and Amines: The Futile Search for the α-Effect in Hydrazine Reactivities

Free Energy Relationships for Reactions of Substituted Benzhydrylium Ions: From Enthalpy over Entropy to Diffusion Control

Photolytic Generation of Benzhydryl Cations and Radicals from Quaternary Phosphonium Salts: How Highly Reactive Carbocations Survive Their First Nanoseconds

Kinetics and mechanism of organocatalytic aza-Michael additions: direct observation of enamine intermediates

Nucleophilicity Parameters of Enamides and Their Implications for Organocatalytic Transformations

Nucleophilic Reactivities of Deoxy Breslow Intermediates: How Does Aromaticity Affect the Catalytic Activities of N-Heterocyclic Carbenes?

Leaving Group Dependence of the Rates of Halogen–Magnesium Exchange Reactions

Guanidines: Highly Nucleophilic Organocatalysts

Electrophilicities of Bissulfonyl Ethylenes

Imidazolidinone-Derived Enamines: Nucleophiles with Low Reactivity

Nucleophilic Addition of Enols and Enamines to α,β-Unsaturated Acyl Azoliums: Mechanistic Studies

How Does Palladium Coordination Affect the Electrophilicities of Allyl Cations? Development of a Robust Kinetic Method for Following Reactions of [(η3-Diarylallyl)Pd(PPh3)2]+ with Nucleophiles

Buildup and Decay of the Optical Absorption in the Ultrafast Photo-Generation and Reaction of Benzhydryl Cations in Solution

Nucleophilicity parameters for designing transition metal-free C-C bond forming reactions of organoboron compounds

Ambident Reactivities of Methylhydrazines

Nucleophilic Reactivities of the Anions of Nucleobases and Their Subunits

2011

Convenient pulse length measuremant of sub-20-fs pulses down to the deep UV via two-photon absorption in bulk materials

Electrophilicities of trans-β-Nitrostyrenes

Hierarchically structured biphenylene-bridged periodic mesoporous organosilica

Role of Structural Order and Excess Energy on Ultrafast Free Charge Generation in Hybrid Polythiophene/Si Photovoltaics Probed in Real Time by Near-Infrared Broadband Transient Absorption

Functionalization of heterocyclic compounds using polyfunctional magnesium and zinc reagents

Characterization of the nucleophilic reactivities of thiocarboxylate, dithiocarbonate and dithiocarbamate anions

Encapsulation of diphenylmethyl phosphonium salts in reverse micelles: Enhanced bimolecular reaction of the photofragments

N-Heterocyclic Carbenes: Organocatalysts with Moderate Nucleophilicity but Extraordinarily High Lewis Basicity

All-inorganic core–shell silica–titania mesoporous colloidal nanoparticles showing orthogonal functionality

pH-Responsive Release of Acetal-Linked Melittin from SBA-15 Mesoporous Silica

Quantification of the Electrophilic Reactivities of Aldehydes, Imines, and Enones

“Liquid-Phase Calcination” of Colloidal Mesoporous Silica Nanoparticles in High-Boiling Solvents

Highly Diastereoselective Arylations of Substituted Piperidines

Synthesis of Polyfunctional Allenes by Successive Copper-Mediated Substitutions

Influence of core-substitution on the ultrafast charge separation and recombination in arylamino core-substituted naphthalene diimides

Flavin Induced DNA Photooxidation and Charge Movement Probed by Ultrafast Transient Absorption Spectroscopy

Trifunctionalization of the Purine Scaffold Using Mg and Zn Organometallic Intermediates

Preparation of Heterocyclic Amines by an Oxidative Amination of Zinc Organometallics Mediated by CuI: A New Oxidative Cycloamination for the Preparation of Annulated Indole Derivatives

Nucleophilicities and Lewis Basicities of Isothiourea Derivatives

The origin of ultrafast proton transfer: multidimensional wave packet motion vs. tunneling

A Farewell to the HSAB Treatment of Ambident Reactivity

Unraveling the flavin-catalyzed photooxidation of benzylic alcohol with transient absorption spectroscopy from sub-pico- to microseconds

2010

Scope and Limitations of Cyclopropanations with Sulfur Ylides

Variation of the Ultrafast Fluorescence Quenching in 2,6-Sulfanyl-Core-Substituted Naphthalenediimides by Electron Transfer

Förster Resonant Energy Transfer in Orthogonally Arranged Chromophores

Effect of the “Supersilyl” Group on the Reactivities of Allylsilanes and Silyl Enol Ethers

Ambident Reactivities of Pyridone Anions

Impact of different PEGylation patterns on the long-term bio-stability of colloidal mesoporous silica nanoparticles

Charged Tags as Probes for Analyzing Organometallic Intermediates and Monitoring Cross-Coupling Reactions by Electrospray-Ionization Mass Spectrometry

Electrophilic Reactivities of 1,2-Diaza-1,3-dienes

Laboratory apparatus for the accurate, facile and rapid determination of visible light photoreaction quantum yields

Ein programmierbares, DNA-basiertes molekulares Ventil für kolloidales, mesoporöses Siliciumoxid

Preparation of Primary Amides from Functionalized Organozinc Halides

Nucleophilic Reactivites of Sulfur Ylides and Related Carbanions: Comparison with Structurally Related Organophosphorus Compounds.

Marcus Analysis of Ambident Reactivity

Probing Cyanocuprates by Electrospray Ionization Mass Spectrometry

i-PrI Acceleration of Negishi Cross-Coupling Reactions

Controlling the delivery kinetics from colloidal mesoporous silicananoparticles with pH-sensitive gates

Oxidation State, Aggregation, and Heterolytic Dissociation of Allyl Indium Reagents

Nucleophilicity and Nucleofugality of Phenylsulfinate (PhSO2−): A Key to Understanding its Ambident Reactivity

Phosphorodiamidate-Directed Metalation of N-Heterocycles using Mg- and Zn-TMP Bases

A Highly Charged Ag6 4+ Core in a DNA-Encapsulated Silver Nanocluster

Structure-Reactivity Relationships in Negishi Cross-Coupling Reactions

Highly diastereoselective Csp3–Csp2 Negishi cross-coupling with 1,2-, 1,3- and 1,4-substituted cycloalkylzinc compounds

Nucleophilic Reactivities of Imide and Amide Anions

2009

A novel ultra-broadband transient spectrometer with microsecond measurement range based on a supercontinuum fiber laser

Femtosecond continuum generation in bulk laser host materials with sub-micro-J pump pulses

Sub-50 fs broadband absorption spectroscopy with tunable excitation: Putting the analysis of the ultrafast dynamics on solid ground

Carbocationic n-endo-trig Cyclizations

Synthesis and Characterization of Novel Quinone Methides: Reference Electrophiles for the Construction of Nucleophilicity Scales

Bio-degradation study of colloidal mesoporous silica nanoparticles: Effect of surface functionalization with organo.silanes and poly(ethylene glycol)

Microsolvated and Chelated Butylzinc Cations: Formation, Relative Stability, and Unimolecular Gas-Phase Chemistry

Kinetics of Bromine-Magnesium Exchange Reactions in Heteroaryl Bromides

Preparation of Polyfunctional Arylmagnesium, Arylzinc, and Benzylic Zinc Reagents by Using Magnesium in the Presence of LiCl

Kinetics of Bromine#Magnesium Exchange Reactions in Substituted Bromobenzenes

Nucleophilicities of the Anions of Arylacetonitriles and Arylpropionitriles in Dimethyl Sulfoxide

Nucleophilic Reactivities of Azulene and Fulvenes

Formation of Organozincate Anions in LiCl-Mediated Zinc Insertion Reactions

Negishi Cross-Couplings Compatible with Unprotected Amide Functions

Nucleophilicity Parameters for Phosphoryl-Stabilized Carbanions and Phosphorus Ylides: Implications for Wittig and Related Olefination Reactions

Palladium-Catalyzed Cross-Couplings of Unsaturated Halides Bearing Relatively Acidic Hydrogen Atoms with Organozinc Reagents

Regio- and Chemoselective Synthesis of Fully Substituted Thiophenes

Radical Catalysis of Kumada Cross-Coupling Reactions Using Functionalized Grignard Reagents

2008

The Key Role of Solvation Dynamics in Intramolecular Electron Transfer: Time-Resolved Photophysics of Crystal Violet Lactone

Aggregation and Reactivity of Organozincate Anions Probed by Electrospray Mass Spectrometry

Efficient mono- and bis-functionalization of 3,6-dichloropyridazine using (tmp)_2 Zn 2MgCl2 2LiCl

Convenient Preparation of Polyfunctional Aryl Magnesium Reagents by a Direct Magnesium Insertion in the Presence of LiCl

Palladium- and Nickel-Catalyzed Cross-Couplings of Unsaturated Halides Bearing Relatively Acidic Protons with Organozinc Reagents

Negishi Cross-Couplings of Unsaturated Halides Bearing Relatively Acidic Hydrogen Atoms with Organozinc Reagents

Reactions of Nitroheteroarenes with Carbanions: Bridging Aromatic, Heteroaromatic, and Vinylic Electrophilicity

Do General Nucleophilicity Scales Exist?

Oxidative Amination of Cuprated Pyrimidine and Purine Derivatives

Ambident Reactivity of the Cyanate Anion

Highly Diastereoselective Addition of Cinnamylzinc Derivatives to r-Chiral Carbonyl Compounds

Preparation of silyl substituted crotylzinc reagents and their highly diastereoselective addition to carbonyl compounds

Regio- and Stereoselective Ring-Opening Reactions of Epoxides with Indoles and Pyrroles in 2,2,2-Trifluoroethanol

Relative Rates of Bromine-Magnesium Exchange Reactions in Substituted Bromobenzene Derivatives

2007

Copper(I)-Mediated Oxidative Cross-Coupling between Functionalized Alkynyl Lithium and Aryl Magnesium Reagents