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Research Area A

2017

Direct Observation of Hemithioindigo-Motor Unidirectionality

Hemiindigo: Highly Bistable Photoswitching at the Biooptical Window

Bistable Photoswitching of Hemithioindigo with Green and Red Light: Entry Point to Advanced Molecular Digital Information Processing

Ingredients to TICT Formation in Donor Substituted Hemithioindigo

"Entstand das Leben in einer RNA-Welt?"

2016

Quantum Yield of Cyclobutane Pyrimidine Dimer Formation Via the Triplet Channel Determined by Photosensitization

Photocontrol of Polar Aromatic Interactions by a Bis-Hemithioindigo Based Helical Receptor

Twisted Hemithioindigo Photoswitches: Solvent Polarity Determines the Type of Light-Induced Rotations

A high-yielding, strictly regioselective prebiotic purine nucleoside formation pathway

UV-Induced Charge Transfer States in DNA Promote Sequence Selective Self-Repair

2015

2’-Methoxyacetophenone: An Efficient Photosensitizer for Cyclobutane Pyrimidine Dimer Formation

Kinetic and Theoretical Studies of Beta-Lactone Reactivity—A Quantitative Scale for Biological Application

Dewar Lesion Formation in Single- and Double-Stranded DNA is Quenched by Neighboring Bases

Anle138b and related compounds are aggregation specific fluorescence markers and reveal high affinity binding to α-synuclein aggregates

Early events of DNA photodamage

Structure and Mechanism of the Caseinolytic Protease ClpP1/2 Heterocomplex from Listeria monocytogenes

Subclass-Specific Labeling of Protein-Reactive Natural Products with Customized Nucleophilic Probes

Photocontrolled chignolin-derived β-hairpin peptidomimetics

2014

“Post-It” Type Connected DNA Created with a Reversible Covalent Cross-Link

Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by ​nucleophosmin

Identification of charge separated states in thymine single strands
A Small Molecule Inhibits Protein Disulfide Isomerase and Triggers the Chemosensitization of Cancer Cells
Making Fast Photoswitches Faster—Using Hammett Analysis to Understand the Limit of Donor–Acceptor Approaches for Faster Hemithioindigo Photoswitches
Watson–Crick Base Pairing Controls Excited-State Decay in Natural DNA
DNA based multi-copper ions assembly using combined pyrazole and salen ligandosides
Ribose-Protonated DNA Base Excision Repair: A Combined Theoretical and Experimental Study
Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA
Primary reactions in photosynthetic reaction centers of Rhodobacter sphaeroides – Time constants of the initial electron transfer
Mechanism of the Decay of Thymine Triplets in DNA Single Strands
Charge separation and charge delocalization identified in long-living states of photoexcited DNA
A Subfamily of Bacterial Ribokinases Utilizes a Hemithioacetal for Pyridoxal Phosphate Salvage
Fingerprinting DNA Oxidation Processes: IR Characterization of the 5-Methyl-2’-Deoxycytidine Radical Cation
Isomerization- and Temperature-Jump-Induced Dynamics of a Photoswitchable β-Hairpin
Photostabilität von 4,4′-Dihydroxythioindigo: ein Mimetikum des Indigo
Excimer formation in 9,10-dichloroanthracene – Solutions and crystals

Omuralide and Vibralactone: Differences in the Proteasome- β-Lactone-γ-Lactam Binding Scaffold Alter Target Preferences

2013

Transition state and ground state properties of the helix–coil transition in peptides deduced from high-pressure studies
Multifunctional Mesoporous Silica Nanoparticles as a Universal Platform for Drug Delivery
A fast analysis method to quantify nanoparticle uptake on a single cell level

Copper-Assisted Click Reactions for Activity-Based Proteomics: Fine-Tuned Ligands and Refined Conditions Extend the Scope of Application

Testing the diffusing boundary model for the helix–coil transition in peptides
Deamination, Oxidation, and C–C Bond Cleavage Reactivity of 5-Hydroxymethylcytosine, 5-Formylcytosine, and 5-Carboxycytosine
The photochemical ring opening reaction of chromene as seen by transient absorption and fluorescence spectroscopy

Total Syntheses and Biological Evaluation of 3-O-Methylfunicone and Its Derivatives Prepared by TMPZnCl·LiCl-Mediated Halogenation and Carbonylative Stille Cross-Coupling

Unexpected non-Hoogsteen–based mutagenicity mechanism of FaPy-DNA lesions

Total Synthesis of the Hypermodified RNA Bases Wybutosine and Hydroxywybutosine and Their Quantification Together with Other Modified RNA Bases in Plant Materials

Synthesis of 5-Hydroxymethyl-, 5-Formyl-, and 5-Carboxycytidine-triphosphates and Their Incorporation into Oligonucleotides by Polymerase Chain Reaction
Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives

Following the energy transfer in and out of a polyproline–peptide

The Two Faces of Potent Antitumor Duocarmycin-Based Drugs: A Structural Dissection Reveals Disparate Motifs for DNA versus Aldehyde Dehydrogenase 1 Affinity

The Mechanism of Caseinolytic Protease (ClpP) Inhibition

2012

Molecular Model of the Ring-Opening and Ring-Closure Reaction of a Fluorinated Indolylfulgide

Light-Switchable Hemithioindigo–Hemistilbene-Containing Peptides: Ultrafast Spectroscopy of the Z → E Isomerization of the Chromophore and the Structural Dynamics of the Peptide Moiety

Synchronous Emission from Nanometric Silver Particles through Plasmonic Coupling on Silver Nanowires

Rugulactone and its Analogues Exert Antibacterial Effects through Multiple Mechanisms Including Inhibition of Thiamine Biosynthesis
The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA
Isotope-Based Analysis of Modified tRNA Nucleosides Correlates Modification Density with Translational Efficiency

Mechanism and Stem-Cell Activity of 5-Carboxycytosine Decarboxylation Determined by Isotope Tracing

Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme
Dynamics of ultraviolet-induced DNA lesions: Dewar formation guided by pre-tension induced by the backbone
Amyloid-Like Structures Formed by Azobenzene Peptides: Light-Triggered Disassembly
Cascaded Photoinduced Drug Delivery to Cells from Multifunctional Core–Shell Mesoporous Silica

Direct Visualization of Dye and Oligonucleotide Diffusion in Silica Filaments with Collinear Mesopores

Low values of 5-hydroxymethylcytosine (5hmC), the “sixth base,” are associated with anaplasia in human brain tumors
Highly Oriented Mesoporous Silica Channels Synthesized in Microgrooves and Visualized with Single Molecule Diffusion
Controlling The Mobility Of Oligonucleotides In The Nanochannels Of Mesoporous Silica
Single-Particle and Ensemble Diffusivities—Test of Ergodicity

2011

Vibrational Spectra of the Ground and the Singlet Excited ππ* State of 6,7-Dimethyl-8-ribityllumazine
Nitro-Phenylalanine: A Novel Sensor for Heat Transfer in Peptides

Flavin Induced DNA Photooxidation and Charge Movement Probed by Ultrafast Transient Absorption Spectroscopy

Trifunctionalization of the Purine Scaffold Using Mg and Zn Organometallic Intermediates
Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions

Light-Triggered Aggregation and Disassembly of Amyloid-Like Structures

Investigation of Excess-Electron Transfer in DNA Double-Duplex Systems
Mechanism of UV-Induced Formation of Dewar Lesions in DNA
The Excited-State Decay of 1-Methyl-2(1H)-pyrimidinone is an Activated Process
Folding and Unfolding of Light-Triggered β-Hairpin Model Peptides

2010

Molecular Driving Forces for Z/E Isomerization Mediated by Heteroatoms: The Example Hemithioindigo

Mechanism of replication blocking and bypass of Y-family polymerase n by bulky acetylamino-fluorene DNA adducts
Mechanism of Acetylaminofluorene-dG Induced Frameshifting by
Reporters in the nanoworld: diffusion of single molecules in mesoporous materials
Effizient Synthesis of Deazaguanosine-Derived tRNA Nucleosides PreQ0, PreQ1 and Archaeosine Using the Turbo-Grignard Method
Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates
Chemical discrimination between dC and 5MedC via their hydroxylamine adducts
Role of Endosomal Escape for Disulfide-Based Drug Delivery from Colloidal Mesoporous Silica Evaluated by Live-Cell Imaging
Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain

DNA photodamage: Study of cyclobutane pyrimidine dimer formation in a locked thymine dinucleotide

A cyanobacterial serine protease of Plasmodium falciparum is targeted to the apicoplast and plays an important role in its growth and development

Relaxation time prediction for a light switchable peptide by molecular dynamics

A Programmable DNA-Based Molecular Valve for Colloidal Mesoporous Silica
Development of a DNA Photoaffinity Probe for the Analysis of 8-OxodG-Binding Proteins in a Human Proteome
Translesion Synthesis of 1,3-GTG Cisplatin DNA Lesions
Antiferromagnetic Coupling of Stacked Cu II–Salen Complexes in DNA

Visualization of the self-assembly of silica nanochannels reveals growth mechanism

Colchicine-Loaded Lipid Bilayer-Coated 50 nm Mesoporous Nanoparticles Efficiently Induce Microtubule Depolymerization upon Cell Uptake
High-Density DNA Functionalization by a Combination of Cu-Catalyzed and Cu-Free Click Chemistry

Increasing the efficiency of the ring-opening reaction of photochromic indolylfulgides by optical pre-excitation

Crystal Structure of a Cisplatin–(1,3-GTG) Cross-Link within DNA Polymerase η

An unlocking/relocking barrier in conformational fluctuations in villin headpiece subdomain

Novel detection scheme for application in pump–repump–probe spectroscopy

DNA (6-4) Photolyases Reduce Dewar Isomers for Isomerization into (6-4) Lesions

2009

NMR Structure of a Monomeric Intermediate on the Evolutionary Optimized Assembly Pathway of a Small Trimerization Domain

Synthesis of Threefold Glycosylated Proteins using Click Chemistry and Genetically Encoded Unnatural Amino Acids

Real-time Nanomicroscopy via Three-Dimensional Single-Particle Tracking
Photochemistry with thermal versus optical excess energy: Ultrafast cycloreversion of indolylfulgides and indolylfulgimides

Once Overlooked, Now Made Visible: ATL Proteins and DNA Repair

Crystal Structure of the T(6-4)C Lesion in Complex with a (6-4) DNA Potolyase and Repair of UV-Induced (6-4) and Dewar Photolesions

Stability and reaction dynamics of trifluorinated indolylfulgides

The archaeal cofactor F0 is a light-harvesting antenna chromophore in eukaryotes

Ring-opening reaction of a trifluorinated indolylfulgide: mode-specific photochemistry after pre-excitation

The complex photo-rearrangement of a heterocyclic N-oxide: Kinetics from picoseconds to minutes

Nanostructured Silica Materials As Drug-Delivery Systems for Doxorubicin: Single Molecule and Cellular Studies

An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies

Structural biology of DNA photolyases and cryptochromes
Synthesis of novel photochromic pyrans via palladium-mediated reactions

beta-Lactones Decrease the Intracellular Virulence of Listeria monocytogenes in Macrophages

A new ground state single electron donor for excess electron transfer studies in DNA

Copper Free "Click" Modification of DNA via Nitrile Oxide-Norbornene 1,3-Dipolar Cycloaddition

beta-Lactam Probes As Selective Chemical-Proteomic Tools for the Identification and Functional Characterization of Resistance Associated Enzymes in MRSA

Ultrafast Hemithioindigo-based peptide-switches

Thymine Dimerization in DNA Model Systems: Cyclobutane Photolesion Is Predominantly Formed via the Singlet Channel

Mutations of the peripheral antenna complex LH2 – correlations of energy transfer time with other functional properties
Phosphorothioation of Oligonucleotides Strongly Influences the Inhibition of Bacterial (M.HhaI) and Human(Dnmt1) DNA Methyltransferases

Wavelength and solvent independent photochemistry: the electrocyclic ring-closure of indolylfulgides

Structurally Refined b-Lactones as Potent Inhibitors of Devastating Bacterial Virulence Factors

Crystal structure analysis of DNA lesion repair and tolerance mechanisms

Molecular dynamics simulation of the acidic compact state of apomyoglobin from yellowfin tuna
Photochromic Bis(thiophen-3-yl)maleimides Studied with Time-Resolved Spectroscopy

Local conformational dynamics in alpha-helices measured by fast triplet transfer

Tuning Single-Molecule Dynamics in Functionalized Mesoporous Silica

Controlled Nucleation of DNA Metallization

Novel Diazirine-Containing DNA Photoaffinity Probes for the Investigation of DNA-Protein-Interactions
Photoreaction from a light generated non-equilibrium state

2008

Accelerated and Efficient Photochemistry From Higher Excited Electronic States in Fulgide Molecules

Recognition and repair of UV lesions in loop structures of duplex DNA by DASH-type cryptochrome

Crystal Structure and Mechanism of a DNA (6-4) Photolyase

Beta-Lactones as Specific Inhibitors of ClpP Attenuate the Production of Extracellular Virulence Factors of Staphylococcus aureus

Detaillierte Einblicke in die Dynamik der Proteinfaltung

Beta-Lactams as Selective Chemical Probes for the in Vivo Labeling of Bacterial Enzymes Involved in Cell Wall Biosynthesis, Antibiotic Resistance, and Virulence

Synthesis and properties of DNA containing a spore photoproduct analog

The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity

Postsynthetic DNA Modification through the Copper-Catalyzed Azide-Alkyne Cycloaddition Reaction

beta-Lactones as Privileged Structures for the Active-Site Labeling of Versatile Bacterial Enzyme Classes

Ultrafast Ring-Closure Reaction of Photochromic Indolylfulgimides Studied with

Monitoring Protein Conformation along the Pathway of Chaperonin-Assisted Folding

Ultrafast dynamics and temperature effects on the quantum efficiency of the ring-opening reaction of a photochromic indolylfulgide

Chemical control of Hemithioindigo-photoisomerization – Substituent-effects on different molecular parts

Ultrafast reaction dynamics of the complete photo cycle of an indolylfulgimide studied by absorption, fluorescence and vibrational spectroscopy

Diffusion of Oriented Single Molecules with Switchable Mobility in Networks of Long Unidimensional Nanochannels

Dissecting the Differences between the a and b Anomers of the Oxidative DNA Lesion FaPydG

Click–Click–Click: Single to Triple Modification of DNA

Selective Detection of 5-Methylcytosine Sites in DNA

PIE: eine multidimensionale Fluoreszenzmethode
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